This indicates an attack attempt to exploit a Remote Code Execution vulnerability in Adobe ColdFusion.
The vulnerability is due to an error in the vulnerable application when handling a maliciously crafted request. A remote attacker may be able exploit this to execute arbitrary code within the context of the application via crafted requests.
Adobe ColdFusion 2016 Update 3 and earlier, ColdFusion 11 update 11 and earlier, ColdFusion 10 Update 22 and earlier
System Compromise: Remote attackers can gain control of vulnerable systems
Apply the most recent upgrade or patch from the vendor.